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2008, Vol 3 No 1, Article 25


Management of Bovine Papilomatosis
with Autogenous Vaccine

S. Khursheed*, M. Naqati and S. Qureshi

Institute of Animal Health and Biological Products- Zukrah,
Department of Animal Husbandry, Kashmir, India
e-mail: (khurshid@kashvet.org)



Successful treatment of papilomatosis in cattle using autogenous vaccine is reported and discussed.


Papilomatosis, Bovine, Autogenous vaccine


Papilomatosis is a neoplastic disease caused by papiloma virus. It occurs more frequently in bovines than other domestic animals (Smith and Jones, 1970). In cattle, cutaneous papiloma can be encountered on almost any part of body. Some papilomas are topographically specific and caused by distinct virus having different antigenic reactions and D.N.A Composition. Therefore a vaccine providing immunity to one of them does not confer immunity to the other. Although, cutaneous papilomas are usually benign but those of alimentary tract may become malignant (Canipo, 1980 and Shrivastava and Sharma, 1991).Successful treatment of papilomatosis has been a great challenge for field practitioners. Surgical intervention may not be possible if a large area is involved and some times aggravates the condition. The present clinical report pertains to the use of an autogenous vaccine in cattle.


A cow aged 7 years having developed multiple, irregular warts on teat surface and its suckling calf with cauliflower like rough multiple growths on lips were presented for treatment. Samples from older growths under aseptic conditions and local analgesia were resected and processed separately. They were finely minced, suspended in saline, filtered through muslin cloth and treated with formalin (by adding 0.5ml of 10% formalin to 100ml of mother solution) to inactivate the virus ( Blood et al, 2002). Antibiotic (Strepto-penicillin 2 mg/ml) was also added to each vial. The auto vaccine was administered @ 1 ml/20 kg body weight intra-dermally. Three injections were given fortnightly to each animal.


The multiple growths on the teats of the cow were interfering with the milking procedure. The calf had contracted infection possibly through direct contact during suckling (Blood et al. loc. cit). Administration of autogenous vaccine caused sloughing of the warts from the affected areas. In both the cases complete recovery took two months. Autogenous vaccine has also been tried for such domestic animals and poultry by Page (1967), Calnek et al (1991), Chawdry (2004) and Blood et al. loc. cit.


  1. Blood, D.C., Radostits, O.M. and Handerson JA (2002) Veterinary medicine 8th edition English language Book Society/ Bailliere Tindall p838-40.

  2. Calnek BW, John Barnest.Beard C.W. Reid W. M. and Yoder (1991) Disease of Poultry 9th edition. Wolfe Publishing Ltd. p690-99.

  3. Canipo MS (1980) Nature, London.286,180.

  4. Chowdary (2004) Poultry planner 10th issue p 11-12

  5. Page EH (1967) J. Am. Vet. Med. Assoc.150, 177.

  6. Shrivastva,A. K and Sharma D.N. (1991) Indian Vet med.J.15:69-70.

  7. Smith,H.A and Johnes T.C (1970) Veterinary Pathology 3rd edition Lea and Febiger, Philidelphia p418-420



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